Circulating brain-derived neurotrophic factor as a potential biomarker in stroke: a systematic review and meta-analysis.

ABSTRACT:

Background

Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. The adaptation and reorganization process following any neuronal damage is regarded as neuroplasticity. Among many factors believed to attribute to this process, Brain-derived Neurotrophic Factor (BDNF) is a neurotrophin coordinating neuroplasticity after various neurological disorders such as stroke.

Methods

We conducted a systematic search in the main electronic medical databases in January 2021. Primarily we want to compare BDNF levels between patients with stroke and healthy controls (HC). Additional aims included investigation of (1) longitudinal changes in the BDNF levels post-stroke, (2) effects of physical training, (3) rep

SUBMITTER: Mojtabavi H 

PROVIDER: S-EPMC8919648 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature