Anterior hippocampal dysfunction in early psychosis: a 2-year follow-up study.

ABSTRACT:

Background

Cross-sectional studies indicate that hippocampal function is abnormal across stages of psychosis. Neural theories of psychosis pathophysiology suggest that dysfunction worsens with illness stage. Here, we test the hypothesis that hippocampal function is impaired in the early stage of psychosis and declines further over the next 2 years.

Methods

We measured hippocampal function over 2 years using a scene processing task in 147 participants (76 individuals in the early stage of a non-affective psychotic disorder and 71 demographically similar healthy control individuals). Two-year follow-up was completed in 97 individuals (50 early psychosis, 47 healthy control). Voxelwise longitudinal analysis of activation in response to scenes was carried out within a hippocampa

SUBMITTER: McHugo M 

PROVIDER: S-EPMC8919704 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature