Systematic illumination of druggable genes in cancer genomes.
Ontology highlight
ABSTRACT:
SUBMITTER: Jiang J
PROVIDER: S-EPMC8919705 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Systematic illumination of druggable genes in cancer genomes.
Jiang Junjie J Yuan Jiao J Hu Zhongyi Z Zhang Youyou Y Zhang Tianli T Xu Mu M Long Meixiao M Fan Yi Y Tanyi Janos L JL Montone Kathleen T KT Tavana Omid O Vonderheide Robert H RH Chan Ho Man HM Hu Xiaowen X Zhang Lin L
Cell reports 20220201 8
By combining 6 druggable genome resources, we identify 6,083 genes as potential druggable genes (PDGs). We characterize their expression, recurrent genomic alterations, cancer dependencies, and therapeutic potentials by integrating genome, functionome, and druggome profiles across cancers. 81.5% of PDGs are reliably expressed in major adult cancers, 46.9% show selective expression patterns, and 39.1% exhibit at least one recurrent genomic alteration. We annotate a total of 784 PDGs as dependent ...[more]
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