Acute Effects of Liothyronine Administration on Cardiovascular System and Energy Metabolism in Healthy Volunteers.

ABSTRACT:

Context

The pharmacokinetics of liothyronine causes concerns for cardiovascular toxicity. While the effects of sustained increase in serum T3 concentrations are well described, little is known on the effects of acute changes in T3 concentrations due to rapid action of thyroid hormone.

Objective

To assess the clinical relevance of transient increase of T3 levels on cardiovascular system and energy metabolism.

Setting

Double-blind, three arms, placebo controlled, cross-over study (ClinicalTrials.gov Identifier: NCT03098433).

Study participants

Twelve volunteers (3 females, 9 males), age 27.7 ± 5.1 years.

Intervention

Oral administration of liothyronine 0.7 mcg/kg, equimolar dose of levothyroxine (0.86 mcg/kg), or placebo in three identical study visits. Bl

SUBMITTER: Chen S 

PROVIDER: S-EPMC8919711 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature