Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Child Growth Trajectories in the First Two Years.

ABSTRACT:

Background

Pregnant women are ubiquitously exposed to per- and polyfluoroalkyl substances (PFAS). Prenatal exposure to PFAS has been associated with lower birth weight but also with excess adiposity and higher weight in childhood. These mixed findings warrant investigation of the relationship between PFAS and dynamic offspring growth.

Objectives

To investigate the association between prenatal PFAS exposure and early-life growth trajectories during the first 2 y.

Methods

Pregnant women (n=3,426) were recruited from 2013 to 2016 from the Shanghai Birth Cohort (SBC) Study, and their children were followed up from birth to 2 y of age. Seven PFAS congeners were quantified in pregnant women's serum during the first trimester. Our study population was restricted to 1,350 chi

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8919954 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature