A Phase 2 Study of Dose-intensified Chemoradiation Using Biologically Based Target Volume Definition in Patients With Newly Diagnosed Glioblastoma.

ABSTRACT:

Purpose

We hypothesized that dose-intensified chemoradiation therapy targeting adversely prognostic hypercellular (TV_HCV) and hyperperfused (TV_CBV) tumor volumes would improve outcomes in patients with glioblastoma.

Methods and materials

This single-arm, phase 2 trial enrolled adult patients with newly diagnosed glioblastoma. Patients with a TV_HCV/TV_CBV >1 cm³, identified using high b-value diffusion-weighted magnetic resonance imaging (MRI) and dynamic contrast-enhanced perfusion MRI, were treated over 30 fractions to 75 Gy to the TV_HCV/TV_CBV with temozolomide. The primary objective was to estimate improvement in 12-month overall survival (OS) versus historical control. Secondary objectives include

SUBMITTER: Kim MM 

PROVIDER: S-EPMC8920120 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature