Targeting NKG2A to boost anti-tumor CD8 T-cell responses in human colorectal cancer.

ABSTRACT: Recently, the inhibitory CD94/NKG2A receptor has joined the group of immune checkpoints (ICs) and its expression has been documented in NK cells and CD8⁺ T lymphocytes in several cancers and some infectious diseases. In colorectal cancer (CRC), we previously reported that NKG2A⁺ tumor-infiltrating lymphocytes (TILs) are predominantly CD8⁺ αβ T cells and that CD94 overexpression and/or its ligand HLA-E were associated with a poor prognosis. This study aimed to thoroughly characterize the NKG2A⁺ CD8⁺ TIL subpopulation and document the impact of NKG2A on anti-tumor responses in CRC. Our findings highlight new features of this subpopulation: (i) enrichment in colorectal tumors compared to paired normal colonic mucosa, (ii) their character

SUBMITTER: Ducoin K 

PROVIDER: S-EPMC8920231 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature