Intermittent glucocorticoid treatment enhances skeletal muscle performance through sexually dimorphic mechanisms.

ABSTRACT: Glucocorticoid steroids are commonly prescribed for many inflammatory conditions, but chronic daily use produces adverse effects, including muscle wasting and weakness. In contrast, shorter glucocorticoid pulses may improve athletic performance, although the mechanisms remain unclear. Muscle is sexually dimorphic and comparatively little is known about how male and female muscles respond to glucocorticoids. We investigated the impact of once-weekly glucocorticoid exposure on skeletal muscle performance comparing male and female mice. One month of once-weekly glucocorticoid dosing improved muscle specific force in both males and females. Transcriptomic profiling of isolated myofibers identified a striking sexually dimorphic response to weekly glucocorticoids. Male myofibers had increased ex

SUBMITTER: Salamone IM 

PROVIDER: S-EPMC8920338 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature