Pterostilbene pre-treatment reduces LPS-induced acute lung injury through activating NR4A1.

ABSTRACT:

Context

Pterostilbene (PTE), a common polyphenol compound, exerts an anti-inflammatory effect in many diseases, including acute lung injury (ALI).

Objective

This study explores the potential mechanism of PTE pre-treatment against lipopolysaccharide (LPS)-induced ALI.

Materials and methods

Sixty Sprague-Dawley rats were divided into control, ALI, 10 mg/kg PTE + LPS, 20 mg/kg PTE + LPS, and 40 mg/kg PTE + LPS groups. At 24 h before LPS instillation, PTE was administered orally. At 2 h before LPS instillation, PTE was again administered orally. After 24 h of LPS treatment, the rats were euthanized. The levels of inflammatory cells and inflammatory factors in the bronchoalveolar lavage fluid (BALF), the expression of nuclear receptor subfamily 4 group A member 1 (NR4A1),

SUBMITTER: Li Y 

PROVIDER: S-EPMC8920364 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature