Drosophila Sirtuin 6 mediates developmental diet-dependent programming of adult physiology and survival.

ABSTRACT: Organisms in the wild experience unpredictable and diverse food availability throughout their lifespan. Over-/under-nutrition during development and in adulthood is known to dictate organismal survival and fitness. Studies using model systems have also established long-term effects of developmental dietary alterations on life-history traits. However, the underlining genetic/molecular factors, which differentially couple nutrient inputs during development with fitness later in life are far less understood. Using Drosophila and loss/gain of function perturbations, our serendipitous findings demonstrate an essential role of Sirtuin 6 in regulating larval developmental kinetics, in a nutrient-dependent manner. The absence of Sirt6 affected ecdysone and insulin signalling and led to accelerated

SUBMITTER: Shukla N 

PROVIDER: S-EPMC8920434 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature