Inhibition of the main protease of SARS-CoV-2 (M^pro) by repurposing/designing drug-like substances and utilizing nature's toolbox of bioactive compounds.

ABSTRACT: The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has resulted in a long pandemic, with numerous cases and victims worldwide and enormous consequences on social and economic life. Although vaccinations have proceeded and provide a valuable shield against the virus, the approved drugs are limited and it is crucial that further ways to combat infection are developed, that can also act against potential mutations. The main protease (M^pro) of the virus is an appealing target for the development of inhibitors, due to its importance in the viral life cycle and its high conservation among different coronaviruses. Several compounds have shown inhibitory potential against M^pro, both in silico and in vitro, with few of them also hav

SUBMITTER: Antonopoulou I 

PROVIDER: S-EPMC8920478 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature