Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.

ABSTRACT:

Background

Childhood overweight and obesity (OW/OB) is a worldwide public health problem, and its genetic risks remain unclear.

Objectives

To investigate risks of OW/OB associated with genetic variances in SEC16B rs543874 and rs10913469, BDNF rs11030104 and rs6265, NT5C2 rs11191580, PTBP2 rs11165675, ADCY9 rs2531995, FAM120A rs7869969, KCNQ1 rs2237892, and C4orf33 rs2968990 in Chinese infants at 12-month old.

Methods

We conducted a case-control study with 734 infants included at delivery and followed up to 12-month old. The classification and regression tree analysis were used to generate the structure of the gene-gene interactions, while the unconditional multivariate logistic regression models were applied to a

SUBMITTER: Mei H 

PROVIDER: S-EPMC8920651 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature