Effect of chemotherapy and radiotherapy on cognitive impairment in colorectal cancer: evidence from Korean National Health Insurance Database Cohort.

ABSTRACT:

Objectives

We investigated the risk of chemotherapy-related and radiotherapy-related cognitive impairment in colorectal cancer patients.

Methods

Medical use data of colorectal cancer patients were obtained from the Korean National Health Insurance Database from 2004 to 2018. We randomly selected 40% of all colorectal cancer patients (n=148,848). Cognitive impairment was defined as having 1 or more International Classification of Diseases, 10th revision diagnostic codes for dementia or mild cognitive impairment. Patients aged 18 years or younger, patients diagnosed with cognitive impairment before colorectal cancer diagnosis (n=8,225), and patients who did not receive primary resection (n=45,320) were excluded. The effects of individual chemotherapy regimens on cognitive impa

SUBMITTER: Kim K 

PROVIDER: S-EPMC8920736 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature