Global morbidity and mortality of central nervous system tuberculosis: a systematic review and meta-analysis.

ABSTRACT:

Background

Tuberculosis (TB) is the second most common cause of death due to a single infectious agent worldwide after COVID-19. Up to 15% of the cases are extrapulmonary, and if it is located in the central nervous system (CNS-TB), it presents high morbidity and mortality. Still, the global epidemiology of CNS-TB remains unknown.

Aim

To estimate the global prevalence and incidence of CNS-TB based on the available literature.

Methods

We systematically searched in MEDLINE, Cochrane Central, Scopus, and LILACS databases (April 2020) and included observational studies evaluating the epidemiology of CNS-TB. Two independent researchers selected and assessed the quality of the studies and extracted relevant data. We performed random-effects model meta-analysis of proportion

SUBMITTER: Navarro-Flores A 

PROVIDER: S-EPMC8920747 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature