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Engineered T cells and their therapeutic applications in autoimmune diseases.

ABSTRACT: Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg cell production. In this review, we report on recent developments in preclinical and clinical studies on CAR-T cells in autoimmune diseases and provide an outlook on opportunities and challenges of CAR-T application in such diseases.

SUBMITTER: Bao L

PROVIDER: S-EPMC8920845 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Engineered T cells and their therapeutic applications in autoimmune diseases.

Bao Lei L Bo Xiao-Chen XC Cao Huai-Wen HW Qian Chen C Wang Zeng Z Li Bin B

Zoological research 20220301 2

Chimeric antigen receptor T cells (CAR-T cells) are engineered recombinant T cells, which were initially used to treat hematopoietic malignancies and are now widely used in the treatment of various diseases. Considering their intrinsic targeting efficiency, CAR-T cells show considerable potential in the treatment of autoimmune diseases. Furthermore, regulatory T cells (Treg), a subset of CD4 T cells exhibiting immunosuppressive functions, have attracted increasing attention regarding CAR-Treg ce ...[more]

PMID: 35008131

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