Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle.

ABSTRACT: Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance in domestic animals, we sequenced the genomes of 28 cattle from warm and cold areas across China. By characterizing the population structure and demographic history, we identified two genetic clusters, i.e., northern and southern groups, as well as a common historic population peak at 30 kilo years ago. Genomic scan of cold-tolerant breeds determined potential candidate genes in the thermogenesis-related pathways that were under selection. Specifically, functional analysis identified a substitution of PRDM16 (p.P779L) in northern cattle, which maintains brown adipocyte formation by boosting thermogenesis-related gene expression, indicating

SUBMITTER: Yan CL 

PROVIDER: S-EPMC8920848 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature