Genome-wide alteration of histone methylation profiles associated with cognitive changes in response to developmental arsenic exposure in mice.

ABSTRACT: Inorganic arsenic is a xenobiotic entering the body primarily through contaminated drinking water and food. There are defined mechanisms that describe arsenic's association with increased cancer incidence, however mechanisms explaining arsenic exposure and neurodevelopmental or aging disorders are poorly defined. In recent years, arsenic effects on epigenome have become a particular focus. We hypothesize that human relevant arsenic exposure during particular developmental windows, or long-term exposure later in life induce pathophysiological neural changes through epigenomic alterations, in particular histone methylation profile, manifesting as cognitive decline. C57BL/6 wild-type mice were continually exposed to sodium arsenite (100 µg/L) in drinking water prior to mating through weaning

SUBMITTER: Fitz NF 

PROVIDER: S-EPMC8920871 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature