Short-Chain Fatty Acids Modulate Healthy Gut Microbiota Composition and Functional Potential.

ABSTRACT: Many studies have focused on the metabolic capacity of human gut microbiota to produce short-chain fatty acids and subsequent effects on host physiology. Given scarce data on how SCFAs produced by gut bacteria participate in cross-feeding to influence community structure and function, we evaluated the potential of SCFAs to modulate human gut microbiota in vitro. We employed anaerobic fecal cultivation in chemically defined medium supplemented with one of nine SCFAs to determine effects on both gut microbial community structure via 16S rRNA sequencing and function via genome reconstruction analysis. Each SCFA displayed significant and unique modulatory potential with respect to the relative abundance of bacterial taxa. Analysis of SCFA-supplemented communities revealed that alterations of i

SUBMITTER: Peterson CT 

PROVIDER: S-EPMC8921067 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature