EIF3a Regulates Colorectal Cancer Metastasis via Translational Activation of RhoA and Cdc42.

ABSTRACT: Tumor metastasis is the major cause of tumor relapse and cancer-associated mortality in colorectal cancer, leading to poor therapeutic responses and reduced survival. eIF3a was previously described as an oncogene. However, its role in colorectal cancer progression and metastasis has not yet been fully investigated. In this study, the expression specificity and predictive value of eIF3a were investigated in clinical samples. The effects of eIF3a on cell proliferation and migration were verified in vivo and in vitro, respectively. The underlying molecular mechanism was revealed by western blotting, immunofluorescence, RNA-binding protein immunoprecipitation, and dual-luciferase reporter gene assays. The results showed that eIF3a was significantly overexpressed in tumor tissues

SUBMITTER: Mei C 

PROVIDER: S-EPMC8921074 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature