Quantification of Brain β-Amyloid Load in Parkinson's Disease With Mild Cognitive Impairment: A PET/MRI Study.

ABSTRACT:

Background

Mild cognitive impairment in Parkinson's disease (PD-MCI) is associated with faster cognitive decline and conversion to dementia. There is uncertainty about the role of β-amyloid (Aβ) co-pathology and its contribution to the variability in PD-MCI profile and cognitive progression.

Objective

To study how presence of Aβ affects clinical and cognitive manifestations as well as regional brain volumes in PD-MCI.

Methods

Twenty-five PD-MCI patients underwent simultaneous PET/3T-MRI with [¹⁸F]flutemetamol and a clinical and neuropsychological examination allowing level II diagnosis. We tested pairwise differences in motor, clinical, and cognitive features with Mann-Whitney U test. We calculated [¹⁸F]flutemetamol (FMM) standardized uptake valu

SUBMITTER: Garon M 

PROVIDER: S-EPMC8921107 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature