Cholecystokinin/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression.

ABSTRACT: Neuropeptides are the most diverse messenger molecules in metazoans and are involved in regulation of daily physiology and a wide array of behaviors. Some neuropeptides and their cognate receptors are structurally and functionally well conserved over evolution in bilaterian animals. Among these are peptides related to gastrin and cholecystokinin (CCK). In mammals, CCK is produced by intestinal endocrine cells and brain neurons, and regulates gall bladder contractions, pancreatic enzyme secretion, gut functions, satiety and food intake. Additionally, CCK plays important roles in neuromodulation in several brain circuits that regulate reward, anxiety, aggression and sexual behavior. In invertebrates, CCK-type peptides (sulfakinins, SKs) are, with a few exceptions, produced by brain neurons o

SUBMITTER: Nassel DR 

PROVIDER: S-EPMC8921109 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature