Metabotypes of flavan-3-ol colonic metabolites after cranberry intake: elucidation and statistical approaches.

ABSTRACT:

Purpose

Extensive inter-individual variability exists in the production of flavan-3-ol metabolites. Preliminary metabolic phenotypes (metabotypes) have been defined, but there is no consensus on the existence of metabotypes associated with the catabolism of catechins and proanthocyanidins. This study aims at elucidating the presence of different metabotypes in the urinary excretion of main flavan-3-ol colonic metabolites after consumption of cranberry products and at assessing the impact of the statistical technique used for metabotyping.

Methods

Data on urinary concentrations of phenyl-γ-valerolactones and 3-(hydroxyphenyl)propanoic acid derivatives from two human interventions has been used. Different multivariate statistics, principal component analysis (PCA), cluster ana

SUBMITTER: Mena P 

PROVIDER: S-EPMC8921115 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature