Proof of concept of a multimodal intravital molecular imaging system for tumour transpathology investigation.

ABSTRACT:

Background

Transpathology highlights the interpretation of the underlying physiology behind molecular imaging. However, it remains challenging due to the discrepancies between in vivo and in vitro measurements and difficulties of precise co-registration between trans-scaled images. This study aims to develop a multimodal intravital molecular imaging (MIMI) system as a tool for in vivo tumour transpathology investigation.

Methods

The proposed MIMI system integrates high-resolution positron imaging, magnetic resonance imaging (MRI) and microscopic imaging on a dorsal skin window chamber on an athymic nude rat. The window chamber frame was designed to be compatible with multimodal imaging and its fiducial markers were customized for precise physical alignment among modalities.

SUBMITTER: Liu Z 

PROVIDER: S-EPMC8921117 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature