Modelled lung deposition and retention of welding fume particles in occupational scenarios: a comparison to doses used in vitro.

ABSTRACT: Translating particle dose from in vitro systems to relevant human exposure remains a major challenge for the use of in vitro studies in assessing occupational hazard and risk of particle exposure. This study aimed to model the lung deposition and retention of welding fume particles following occupational scenarios and subsequently compare the lung doses to those used in vitro. We reviewed published welding fume concentrations and size distributions to identify input values simulating real-life exposure scenarios in the multiple path particle dosimetry (MPPD) model. The majority of the particles were reported to be below 0.1 μm and mass concentrations ranged between 0.05 and 45 mg/m³. Following 6-h exposure to 5 mg/m³ with a count median diameter of 50 nm, the tracheob

SUBMITTER: McCarrick S 

PROVIDER: S-EPMC8921161 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature