Global profiling reveals common and distinct N6-methyladenosine (m6A) regulation of innate immune responses during bacterial and viral infections.

ABSTRACT: N⁶-methyladenosine (m⁶A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA biology. While m⁶A modifications during numerous viral infections have been described, the role of m⁶A in innate immune response remains unclear. Here, we examined cellular m⁶A epitranscriptomes during infections of Pseudomonas aeruginosa and herpes simplex virus type 1 (HSV-1), and lipopolysaccharide (LPS) stimulation to identify m⁶A-regulated innate immune response genes. We showed that a significant portion of cellular genes including many innate immune response genes underwent m⁶A modifications in 5'UTR and 3'UTR. We identified common and distinct m⁶A-modified genes under different stimulating

SUBMITTER: Feng J 

PROVIDER: S-EPMC8921188 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature