Microengineered filters for efficient delivery of nanomaterials into mammalian cells.

ABSTRACT: Intracellular delivery of nanomaterials into the cells of interest has enabled cell manipulation for numerous applications ranging from cell-based therapies to biomedical research. To date, different carriers or membrane poration-based techniques have been developed to load nanomaterials to the cell interior. These biotools have shown promise to surpass the membrane barrier and provide access to the intracellular space followed by passive diffusion of exogenous cargoes. However, most of them suffer from inconsistent delivery, cytotoxicity, and expensive protocols, somewhat limiting their utility in a variety of delivery applications. Here, by leveraging the benefits of microengineered porous membranes with a suitable porosity, we demonstrated an efficient intracellular loading of diverse n

SUBMITTER: Morshedi Rad D 

PROVIDER: S-EPMC8921284 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature