Bone metabolism in patients with type 1 neurofibromatosis: key role of sun exposure and physical activity.

ABSTRACT: Bone metabolism has been rarely investigated in children affected by Neurofibromatosis type 1 (NF1). Aim of the present study was to assess bone mineral metabolism in children and adults NF1 patients, to determine the relevant factors potentially involved in the development of reduced bone mineral density (BMD), and provide possible therapeutic intervention in NF1 patients. 114 NF1 patients and sex and age matched controls were enrolled into the study. Clinical and biochemical factors reflecting bone metabolism were evaluated. Factors potentially affecting BMD were also investigated including: physical activity, sun exposure, vitamin D intake. Whenever the presence of vitamin D deficiency was recorded, cholecalciferol supplementation was started and z-score data obtained at Dual-Energy X-r

SUBMITTER: Ferrara UP 

PROVIDER: S-EPMC8921306 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature