Cognitive glucose sensitivity-proposing a link between cognitive performance and reliance on external glucose uptake.

ABSTRACT: Existing evidence on the effects of glucose supplementation on cognitive performance appears inconclusive. Metabolic switching offers an approach to explain such incoherent findings based on differences in cognitive functioning after fasting. We propose a new construct, cognitive glucose sensitivity (CGS), which quantifies individual performance gain due to glucose supplementation. We tested the hypothesis that the effects of glucose ingestion depend on CGS, cognitive task domain, and sex. In addition, the relationship between CGS and body mass index (BMI) was examined. Seventy-one participants (48 female) were tested in two conditions each (deprivation baseline vs. glucose supplementation), performing tasks from different cognitive domains (memory and executive functioning). We found sign

SUBMITTER: Neukirchen T 

PROVIDER: S-EPMC8921321 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature