A biophysical perspective of the regulatory mechanisms of ezrin/radixin/moesin proteins.

ABSTRACT: Many signal transductions resulting from ligand-receptor interactions occur at the cell surface. These signaling pathways play essential roles in cell polarization, membrane morphogenesis, and the modulation of membrane tension at the cell surface. However, due to the large number of membrane-binding proteins, including actin-membrane linkers, and transmembrane proteins present at the cell surface, the molecular mechanisms underlying the regulation at the cell surface are yet unclear. Here, we describe the molecular functions of one of the key players at the cell surface, ezrin/radixin/moesin (ERM) proteins from a biophysical point of view. We focus our discussion on biophysical properties of ERM proteins revealed by using biophysical tools in live cells and in vitro reconstitution systems

SUBMITTER: Senju Y 

PROVIDER: S-EPMC8921360 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature