Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology.

ABSTRACT: Aquaporins (AQPs) are multifunctional transmembrane channel proteins permeable to water and an expanding array of solutes. AQP-mediated ion channel activity was first observed when purified AQP0 from bovine lens was incorporated into lipid bilayers. Electrophysiological properties of ion-conducting AQPs since discovered in plants, invertebrates, and mammals have been assessed using native, reconstituted, and heterologously expressed channels. Accumulating evidence is defining amino acid residues that govern differential solute permeability through intrasubunit and central pores of AQP tetramers. Rings of charged and hydrophobic residues around pores influence AQP selectivity, and are candidates for further work to define motifs that distinguish ion conduction capability, versus strict wate

SUBMITTER: Henderson SW 

PROVIDER: S-EPMC8921385 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature