Symptom-severity-related brain connectivity alterations in functional movement disorders.

ABSTRACT:

Background

Functional movement disorders, a common cause of neurological disabilities, can occur with heterogeneous motor manifestations including functional weakness. However, the underlying mechanisms related to brain function and connectivity are unknown.

Objective

To identify brain connectivity alterations related to functional weakness we assessed network centrality changes in a group of patients with heterogeneous motor manifestations using task-free functional MRI in combination with different network centrality approaches.

Methods

Task-free functional MRI was performed in 48 patients with heterogeneous motor manifestations including 28 patients showing functional weakness and 65 age- and sex-matched healthy controls. Functional connectivity differences were as

SUBMITTER: Mueller K 

PROVIDER: S-EPMC8921488 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature