MIR17HG polymorphisms contribute to high-altitude pulmonary edema susceptibility in the Chinese population.

ABSTRACT: High-altitude pulmonary edema (HAPE) is a common acute altitude sickness. This study was designed to investigate the effect of MIR17HG polymorphisms on HAPE risk in the Chinese population. The Agena MassARRAY platform was used to genotype six single-nucleotide polymorphisms (SNPs) in the MIR17HG gene in 244 HAPE patients and 243 non-HAPE controls. The odds ratio (OR) and 95% confidence interval were used to evaluate the association between each MIR17HG polymorphisms and the risk of HAPE under a polygenetic model. Statistical analysis was performed using the χ² test. Multifactor dimensionality reduction (MDR) analysis was used to analyze the impacts of SNP-SNP interactions on the risk of HAPE. According to the allele model, the HAPE risk of people with the rs7318578 A allele of M

SUBMITTER: Si L 

PROVIDER: S-EPMC8921515 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature