MetaLogo: a heterogeneity-aware sequence logo generator and aligner.

ABSTRACT: Sequence logos are used to visually display conservations and variations in short sequences. They can indicate the fixed patterns or conserved motifs in a batch of DNA or protein sequences. However, most of the popular sequence logo generators are based on the assumption that all the input sequences are from the same homologous group, which will lead to an overlook of the heterogeneity among the sequences during the sequence logo making process. Heterogeneous groups of sequences may represent clades of different evolutionary origins, or genes families with different functions. Therefore, it is essential to divide the sequences into different phylogenetic or functional groups to reveal their specific sequence motifs and conservation patterns. To solve these problems, we developed MetaLogo,

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8921662 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature