Total observed error, total allowable error, and QC rules for canine serum and urine cortisol achievable with the Immulite 2000 Xpi cortisol immunoassay.

ABSTRACT: Determining a simple quality control (QC) rule for daily performance monitoring depends on the desired total allowable error (TEa) for the measurand. When no consensus TEa exists, the classical approach of QC rule validation cannot be used. Using the results of previous canine serum and urine cortisol validation studies on the Immulite 2000 Xpi, we applied a reverse engineering approach to QC rule determination, arbitrarily imposing sigma = 5, and determining the resulting TEa for the QC material (QCM; TEa_QCM) and the resulting probability of error detection (P_ed) for each QC rule. For the simple QC rule 1_2.5S with P_ed = 0.96 and probability of false rejection (P_fr) = 0.03, the associated TEa_QCM were 20% and 35% for serum an

SUBMITTER: Korchia J 

PROVIDER: S-EPMC8921817 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature