Exosomes in Age-Related Cognitive Decline: Mechanistic Insights and Improving Outcomes.

ABSTRACT: Aging is the most prominent risk factor for cognitive decline, yet behavioral symptomology and underlying neurobiology can vary between individuals. Certain individuals exhibit significant age-related cognitive impairments, while others maintain intact cognitive functioning with only minimal decline. Recent developments in genomic, proteomic, and functional imaging approaches have provided insights into the molecular and cellular substrates of cognitive decline in age-related neuropathologies. Despite the emergence of novel tools, accurately and reliably predicting longitudinal cognitive trajectories and improving functional outcomes for the elderly remains a major challenge. One promising approach has been the use of exosomes, a subgroup of extracellular vesicles that regulate intercellul

SUBMITTER: Duggan MR 

PROVIDER: S-EPMC8921862 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature