A novel intra-ventricular assist device enhances cardiac performance in normal and acutely failing isolated porcine hearts.

ABSTRACT:

Background

We recently demonstrated that a novel intra-ventricular membrane pump (IVMP) was able to increase the pump function of isolated beating porcine hearts. In follow-up, we now investigated the impact of the IVMP on myocardial oxygen consumption and total mechanical efficiency (TME) and assessed the effect of IVMP-support in acutely failing hearts.

Methods

In 10 ex vivo beating porcine hearts, we studied hemodynamic parameters, as well as arterial and coronary venous oxygen content. We assessed cardiac power (CP), myocardial oxygen consumption (MVO₂), and TME (CP divided by MVO₂) under baseline conditions and during IVMP-support. Additionally, five isolated hearts were subjected to global hypoxia to investigate the effects of IVMP-support on CP u

SUBMITTER: van Dort DI 

PROVIDER: S-EPMC8921884 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature