IL-34 in hepatoblastoma cells potentially promote tumor progression via autocrine and paracrine mechanisms.

ABSTRACT: Hepatoblastoma is the most common pediatric liver tumor, but little research has been done on the role of macrophages in hepatoblastoma. The purpose of this study was to gain insight into potential roles for macrophages in hepatoblastoma. Paraffin-embedded specimens from 56 patients who underwent surgical resection were examined with immunohistochemical staining for the macrophage-specific markers, Iba1 and CD163. Significant differences were seen among histological subtypes. Significantly increased numbers of macrophages were detected in embryonal components compared to fetal components in the mixed epithelial type. In vitro studies using human monocyte-derived macrophages and two hepatoblastoma cell lines (HepG2 and Huh6) were performed. Conditioned medium from these cell lines induced i

SUBMITTER: Irie T 

PROVIDER: S-EPMC8921897 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature