Clinical and molecular assessment of an onco-immune signature with prognostic significance in patients with colorectal cancer.

ABSTRACT: Understanding the complex tumor microenvironment is key to the development of personalized therapies for the treatment of cancer including colorectal cancer (CRC). In the past decade, significant advances in the field of immunotherapy have changed the paradigm of cancer treatment. Despite significant improvements, tumor heterogeneity and lack of appropriate classification tools for CRC have prevented accurate risk stratification and identification of a wider patient population that may potentially benefit from targeted therapies. To identify novel signatures for accurate prognostication of CRC, we quantified gene expression of 12 immune-related genes using a medium-throughput NanoString quantification platform in 93 CRC patients. Multivariate prognostic analysis identified a combined four-

SUBMITTER: Ahluwalia P 

PROVIDER: S-EPMC8921909 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature