Relationship of Enhanced Liver Fibrosis Score with Pediatric Nonalcoholic Fatty Liver Disease Histology and Response to Vitamin E or Metformin.

ABSTRACT:

Objectives

To study the diagnostic performance of the enhanced liver fibrosis score (ELF) for detecting different stages of fibrosis and its usefulness in detecting histologic response to vitamin E or metformin in children with nonalcoholic fatty liver disease who participated in the Vitamin E or Metformin for the Treatment Of NAFLD In Children (TONIC) trial.

Study design

ELF was measured at baseline and weeks 24, 48, and 96 on sera from 166 TONIC participants. Associations between ELF with baseline and end of trial (EOT) fibrosis stages and other histologic features were assessed using χ² tests and logistic regression models.

Results

ELF was significantly associated with severity of fibrosis at baseline and EOT. ELF areas under the curve for discriminating

SUBMITTER: Gawrieh S 

PROVIDER: S-EPMC8922020 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature