Evaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The association between statin-induced reduction in low-density lipoprotein cholesterol (LDL-C) levels and the absolute risk reduction of individual, rather than composite, outcomes, such as all-cause mortality, myocardial infarction, or stroke, is unclear.

Objective

To assess the association between absolute reductions in LDL-C levels with treatment with statin therapy and all-cause mortality, myocardial infarction, and stroke to facilitate shared decision-making between clinicians and patients and inform clinical guidelines and policy.

Data sources

PubMed and Embase were searched to identify eligible trials from January 1987 to June 2021.

Study selection

Large randomized clinical trials that examined the effectiveness of statins in reducing total m

SUBMITTER: Byrne P 

PROVIDER: S-EPMC8922205 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature