Abatacept to treat chronic intestinal pseudo-obstruction in five systemic sclerosis patients with a description of the index case.

ABSTRACT: Chronic intestinal pseudo-obstruction is a severe complication of systemic sclerosis. Inflammatory neuropathy and immunological alterations have a prominent role in the development of systemic sclerosis-related chronic intestinal pseudo-obstruction and immunomodulation might be beneficial in this context. An accidental observation of a patient with juvenile arthritis and a biopsy-proven diagnosis of autoimmune ganglionitis led us to experiment with a new approach to treat systemic sclerosis-related chronic intestinal pseudo-obstruction. In our arthritis patient, the severity and frequency of recurrent episodes of chronic intestinal pseudo-obstruction and aspiration pneumonia were reduced whenever steroids were used to treat arthritic flares, which dramatically improved with abatacept thera

SUBMITTER: Vigone B 

PROVIDER: S-EPMC8922584 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature