Mendelian randomization study of circulating lipids and biliary tract cancer among East Asians.

ABSTRACT:

Background

Associations of High-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol (CHL), and triglyceride (TRG) concentrations with risk of biliary tract cancer (BtC) were conflicting in observational studies. We aim to investigate the causal link between circulating lipids and BtC using genetic information.

Methods

Single nucleotide polymorphisms of the four circulating lipids (n = 34,421) and BtC (418 cases and 159,201 controls) were retrieved from two independent GWAS studies performed in East Asian populations. Two-sample univariate and multivariate Mendelian Randomization (MR) analyses were conducted to determine the causal link between circulating lipids and BtC.

Results

No significant horizontal pleiotropy was d

SUBMITTER: Wang J 

PROVIDER: S-EPMC8922750 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature