Enhanced tumor accumulation and therapeutic efficacy of liposomal drugs through over-threshold dosing.

ABSTRACT:

Background

Most intravenously administered drug-loaded nanoparticles are taken up by liver Kupffer cells, and only a small portion can accumulate at the tumor, resulting in an unsatisfactory therapeutic efficacy and side effects for chemotherapeutic agents. Tumor-targeted drug delivery proves to be the best way to solve this problem; however, the complex synthesis, or surface modification process, together with the astonishing high cost make its clinical translation nearly impossible.

Methods

Referring to Ouyang's work and over-threshold dosing theory in general, blank PEGylated liposomes (PEG-Lipo) were prepared and used as tumor delivery enhancers to determine whether they could significantly enhance the tumor accumulation and in vivo antitumor efficacy of co-injected lipo

SUBMITTER: Ao H 

PROVIDER: S-EPMC8922779 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature