Exploration of induced sputum BIRC3 levels and clinical implications in asthma.

ABSTRACT:

Background

Baculoviral IAP repeat-containing 3 (BIRC3) which encodes a member of the IAP family of proteins upregulated in the asthma expression profile dataset. However, there was few research on studying the clinical implication of BIRC3 in asthma.

Objective

To validate BIRC3 expression and its clinical implications in induced sputum of asthma.

Methods

Based on the GSE76262 (118 asthma cases and 21 healthy controls) dataset, differentially expressed genes were screened using R software. Subsequently, BIRC3 mRNA and protein were clinically verified in induced sputum samples through quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA). Besides, the correlations between BIRC3 expression and asthmatic eosinophilic/alle

SUBMITTER: Du L 

PROVIDER: S-EPMC8922789 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature