Non-vitamin K antagonist oral anticoagulants in venous thromboembolism patients: a meta-analysis of real-world studies.

ABSTRACT:

Background

The real-world studies on recurrent venous thromboembolism (VTE) and bleeding events of non-vitamin K antagonist oral anticoagulants (NOACs) in VTE patients have reported conflicting findings. Our study aimed to provide the direct comparison evidence of different NOACs for VTE patients in clinical practice settings.

Methods

Search of the medical literature was conducted using PubMed, Web of Science, EMBASE, Clinical Trials.gov, and the Cochrane Library from inception to March 22, 2021. Among the 19,996 citations retrieved, a total of 63,144 patients from 6 studies were analyzed. Clinical outcomes included recurrent VTE, death, and different bleeding events.

Results

Adjusted hazard ratio (HR) analysis suggested that apixaban had significant lower bleeding ri

SUBMITTER: Liu ZY 

PROVIDER: S-EPMC8922817 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature