Maternal exposure to CeO₂NPs derails placental development through trophoblast dysfunction mediated by excessive autophagy activation.

ABSTRACT:

Background

The increasing use of cerium dioxide nanoparticles (CeO₂NPs) in biomedical field has attracted substantial attention about their potential risks to human health. Recent studies have shown that nanoparticles can induce placental dysfunction and even fetal abortion, but a more detailed mechanism of nanoparticles affecting placental development remains elusive.

Results

Here, we constructed a mouse exposure model with different doses of CeO₂NPs (2.5, 4, 5, 7.5, and 10 mg kg^-1 day^-1, average particle size 3-5 nm), finding that intravenous exposure to pregnant mice with CeO₂NPs could cause abnormal placental development. Deposited nanoparticles were able to be observed in the placental trophoblast at doses of 5 and

SUBMITTER: Chen Z 

PROVIDER: S-EPMC8922923 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature