Fibrinolytic assays in bleeding of unknown cause: Improvement in diagnostic yield.

ABSTRACT:

Introduction

Analysis of fibrinolytic disorders is challenging and may potentially lead to underdiagnosis of patients with an increased bleeding tendency.

Aim

To compare clinical characteristics, laboratory measurements, and treatment modalities in a monocenter cohort of patients in whom fibrinolytic studies were performed.

Methods

Retrospective study of patients in whom fibrinolytic studies were performed between January 2016 and February 2020 in the Hemophilia Treatment Center, Nijmegen-Eindhoven-Maastricht, the Netherlands. Plasminogen activator inhibitor type 1 (PAI-1) antigen and activity level, α2-antiplasmin activity, tissue plasminogen activator, and euglobulin clot lysis time (ECLT) before and after venous compression were determined in all patients. Data of

SUBMITTER: Valke LLFG 

PROVIDER: S-EPMC8922970 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature