Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction.

ABSTRACT: Infralimbic cortical (IL) manipulations indicate that this region mediates extinction learning and suppresses cocaine seeking following cocaine self-administration. However, little work has recorded IL activity during the inhibition of cocaine seeking due to the difficulty of determining precisely when cocaine-seeking behaviour is inhibited within a cocaine-seeking session. The present study used in vivo electrophysiology to examine IL activity across extinction as well as during cocaine self-administration and reinstatement. Sprague-Dawley rats underwent 6-h access cocaine self-administration in which the response lever was available during discrete signalled trials, a procedure which allowed for the comparison between epochs of cocaine seeking versus the inhibition thereof. Subsequently,

SUBMITTER: Muller Ewald VA 

PROVIDER: S-EPMC8922975 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature