Interactome and evolutionary conservation of Dictyostelid small GTPases and their direct regulators.

ABSTRACT: GTP binding proteins known as small GTPases make up one of the largest groups of regulatory proteins and control almost all functions of living cells. Their activity is under, respectively, positive and negative regulation by guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), which together with their upstream regulators and the downstream targets of the small GTPases form formidable signalling networks. While genomics has revealed the large size of the GTPase, GEF and GAP repertoires, only a small fraction of their interactions and functions have yet been experimentally explored. Dictyostelid social amoebas have been particularly useful in unravelling the roles of many proteins in the Rac-Rho and Ras-Rap families of GTPases in directional cell migration and

SUBMITTER: Forbes G 

PROVIDER: S-EPMC8923023 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature