Immune checkpoint inhibitor induced thyroid dysfunction is a frequent event post-treatment in NSCLC.

ABSTRACT:

Introduction

Thyroid dysfunction is the most frequent endocrine immune related adverse event (irAE) in non-small cell lung cancer (NSCLC), typically arising 3-6 months into immune checkpoint inhibitor (ICI) therapy, but arising after ICI cessation, in some cases. Due to limited post-treatment adverse event reporting requirements on ICI trials, the incidence of ICI-induced thyroid dysfunction arising after therapy is unclear. We investigated ICI-induced thyroid dysfunction in a cohort of 294 NSCLC patients, with a specific focus on the post-treatment setting.

Methods

Retrospective analysis of ICI-induced thyroid dysfunction (clinically acted upon or laboratory only) was performed in 294 UCLA NSCLC patients treated 2012-2018. Clinically acted upon thyroid dysfunction was defin

SUBMITTER: Zhou N 

PROVIDER: S-EPMC8923054 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature